PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 1, 1999

 Article

Bcl-2 and p53 Immunoprofile in Kaposi's Sarcoma

Preedashnie PILLAY, Runjan CHETTY, Roshilla REDDY

Department of Pathology, University of Natal Medical School, Durban, South Africa

 

Seventy three cases of Kaposi's sarcoma (KS) from the 3 histological subtypes (patch, plaque and nodular) were assessed for bcl-2 and p53 protein expression. The aim was determine the level of expression of these proteins in KS and in the different subtypes. Commercially available antibodies to bcl-2 and p53 were applied after both microwave and pressure cooking antigen retrieval. Bcl-2 immunoexpression increased from the patch stage (36%) to the plaque stage (45%) to the nodular stage (70.83%). Better immunostaining for bcl-2 was obtained after pressure cooking. p53 on the other hand, was not expressed in the patch or plaque stages, but 54.16% of cases in the nodular stage were immunopositive. These results show a progression of immunoexpression of both bcl-2 and p53 from the early histological stages to the late tumor stage, implying that these proteins are upregulated late in the evolution of KS. Pathology & Oncology Research, Vol 5, Nr 1, 17-20, 1999

Key words: bcl-2, p53, Kaposi's sarcoma


Received: Oct 10, 1998; accepted: Dec 10, 1998
Correspondence: Preedashnie PILLAY, Department of Pathology, University of Natal Medical School, Private Bag 7, Congella Durban 4013, South Africa; Tel: 27-31-2604442, Fax: 27-31-252711; E-mail: pillayp11@med.und.ac.za

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