Occult Thyroid Pathology in a Child with Acquired Immunodeficiency Syndrome

Case Report and Review of the Drug-related Pathology in Pediatric Acquired Immunodeficiency Syndrome

Consolato SERGI1, Thomas BÖHLER2, Günther SCHÖNRICH3, Hauke SIEVERTS4, Stephanie U ROTH5, Klaus-Michael DEBATIN2, Herwart F OTTO1

1Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Department of Pediatrics, University of Ulm, Ulm, Germany
3Institute of Hygiene and Microbiology, University of Heidelberg, Heidelberg, Germany
4Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
5Department of Neuropathology, University of Heidelberg, Heidelberg, Germany


A 11-year-old boy with acquired immunodeficiency syndrome (AaS), Varicella-zoster virus (VZV) infection and long-term antiviral treatment suffered from a disorder of contractility of the left ventricle of the heart. Following severe unmanageable vomiting, the patient died and the postmortem examination showed marked involution of the lymphatic system, multiple foci of fibrosis of both ventricles of the heart, and regressive changes of the thyroid gland. Biochemical values of the thyroid gland function were, however, not altered. Neither human immunodeficiency virus-related p24 antigen, nor VZV DNA sequences were found in the thyroid gland. Regressive changes of the thyroid gland can probably occur before its function fails. By analyzing the possible etiologies, the endocrine toxicity of a long-term antiviral treatment should be taken into account. Pathology & Oncology Research, Vol 6, Nr 3, 227-232, 2000

Key words: HIV; AaS; childhood; thyroid gland; pathology

Received: Dec 15, 1999; accepted: Mar 10, 2000
Correspondence: Consolato SERGI, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221 Heidelberg D-69120, Germany; Tel: +49-6221-56-26-70, Fax: +49-6221-56-52-51; E-mail:

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