PATHOLOGY & ONCOLOGY RESEARCHVol. 6 No. 4, 2000

 Report

Pleomorphic Liposarcoma of a Young Woman Following Radiotherapy for Epithelioid Sarcoma

Zsolt OROSZ1, Béla ROHONYI2, Antal LUKSANDER3, János SZÁNTÓ4

1Department of Human and Experimental Tumor Pathology, National Institute of Oncology, Budapest, Hungary
2Department of Pathology, Erzsébet Hospital, Sopron, Hungary
3Department of Surgery, Erzsébet Hospital, Sopron, Hungary
4Medical and Health Science Center, Department of Oncology, University of Debrecen, Debrecen, Hungary

 

A case of a metachronous epithelioid sarcoma and pleomorphic liposarcoma in a young woman is described. The first tumor was an epithelioid sarcoma (ES) with focal rhabdoid features localised in the left calf while the second lesion developed seven years later in the same region was diagnosed as pleomorphic liposarcoma resembling myxofibrosarcoma (''myxoid variant of malignant fibrous histiocytoma'') predominantly composed of moderately differentiated spindle cells. Multiple foci of uni- and plurivacuolated lipoblasts were seen. Following the resection of ES the patient received 57 Gy radiation to the region, therefore we regarded the second tumor as a radiation induced liposarcoma. A further interesting feature of this case is that the development of pleomorphic liposarcoma preceded by 6 months the solitary right parabronchial metastasis of ES and after 4 months of metastasectomy a third tumor developed at the site of the first lesion. This tumor showed dedifferentiation toward pleomorphic malignant fibrous histiocytoma. Our case represents a unique case of postirradiation liposarcoma developed on the base of ES. Pathology & Oncology Research, Vol 6, Nr 4, 287-291, 2000

Key words: epithelioid sarcoma; pleomorphic liposarcoma; postirradiation sarcoma


Received: Mar 30, 2000; accepted: Nov 4, 2000
Correspondence: Zsolt OROSZ, Department of Human and Experimental Tumor Pathology, National Institute of Oncology, Ráth György u. 7-9. Budapest H-1122, Hungary; Tel: 36-1-2248600 / 1376, Fax: 36-1-2248620; E-mail: zso@oncol.hu

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