PATHOLOGY & ONCOLOGY RESEARCHVol. 6 No. 4, 2000

 Report

Placental Site Trophoblastic Tumor

Clinical and Pathological Report of Two Cases

Gabriella ARATÓ1, Vilmos FÜLÖP2, Péter DEGRELL3, Iván SZIGETVÁRI2

1Institute of Pathology, Semmelweis University, Faculty of Health Sciences, Budapest, Hungary
22 Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Health Sciences, Budapest, Hungary
3Department of Pathology, County Hospital of Borsod-Abauj-Zemplen, Miskolc, Hungary

 

Placental site trophoblastic tumor (PSTT) is the rarest disease of the gestational trophoblast. Our two cases will be interesting not only because of the rarity of the disease, but because both were recognized before operation. Since the tumor cells are lined up tightly side by side, this disease must be distinguished primarily from tumors of epithelial origin. The authors highlight that the diagnosis should rely on intense hPL-positivity as well as the ultrastructural image of the tumor. In histologically equivocal cases, the determination of hPL, hCG, and MIB-1 immunologic markers can be recommended as routinely performed morphological examinations. Serum hCG monitoring is recommended to follow the evolution of the tumor. Pathology & Oncology Research, Vol 6, Nr 4, 292-294, 2000

Key words: placental trophoblastic tumor;, choriocarcinoma; immunohistology; intermediate trophoblast


Received: Jul 12, 2000; accepted: Dec 10, 2000
Correspondence: Gabriella ARATÓ, Institute of Pathology, Semmelweis University, Faculty of Health Sciences, Szabolcs u. 35. Budapest H-1135, Hungary

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