PATHOLOGY & ONCOLOGY RESEARCHVol. 7 No. 1, 2001

 Review

Molecular Genetic Abnormalities in the Pathogenesis of Human Lung Cancer

Eva FORGACS1, Sabine ZÖCHBAUER-MÜLLER1, Edit OLÁH2, John D MINNA1

1Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
2Department of Molecular Biology, National Institute of Oncology, Budapest, Hungary

 

In the past few years our knowledge of the molecular pathogenesis of lung cancer has significantly increased. There are several molecular mechanisms involved in the multistage carcinogenesis through which respiratory epithelial cells become preneoplastic and then invasive cancer. In this review we summarize some of these changes including, genomic alterations such as loss of heterozygosity and microsatellite alterations, autocrine-paracrine loops, alterations in oncogenes and tumor suppressor genes, tumor angiogenesis, aberrant promoter methylation and inherited predisposition to lung cancer. Translation of these findings to the clinic is also discussed. Pathology & Oncology Research, Vol 7, Nr 1, 6-13, 2001

Key words: oncogene; tumor suppressor gene; autocrine; signal transduction; cell cycle; mutation; methylation; telomerase; angiogenesis; preneoplasia


Received: Dec 6, 2000; accepted: Jan 12, 2001
Correspondence: John D MINNA, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd Dallas 75390-8593, USA; Tel: 214-648-4900, Fax: 214-648-4940; E-mail: John.Minna@UTSouthwestern.edu

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