Prostatic Intraepithelial Neoplasia and Apoptosis in Benign Prostatic Hyperplasia Before and After the Chernobyl Accident in Ukraine

Alexander F VOSIANOV1, Alina M ROMANENKO1, Larisa B ZABARKO1, Béla SZENDE2, Ching Y WANG3, Steven LANDAS3, Gabriel P HAAS3

1Institute of Urology and Nephrology, Departments of Pathology and Urology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine
2First Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary
3Departments of Urology and Pathology, State University of New York Health Science Center, Syracuse, USA


The prevalence of prostatic intraepithelial neoplasia (PIN) in men who underwent surgery for benign prostatic hyperplasia (BPH) before and after the Chernobyl nuclear accident was studied. BPH samples were obtained by adenomectomy from 45 patients operated in 1984 before the accident (Group I), and 47 patients from the low contamined Kiev City (Group II) and 76 from high contaminated area (Group III) operated between 1996 and 1998. Their BPH samples were examined histologically and immunohistochemically. The incidences of prostatic intraepithelial neoplasia (PIN) and high grade PIN (HGPIN) were 15.5 and 11.1% in Group I, 29.8 and 14.9% in Group II, and 35.5 and 19.7% in Group III. The difference between the incidences of PIN in Group I and III is signficant (p<0.02). There was increased apoptosis in areas of PIN in Group II and III as compared to Group I (p<0.001). Since apoptosis has been shown to be associated with ionizing radiation and it is now found to be associated with PIN in patients diagnosed after the Chernobyl nuclear accident, this suggests that lon-term low dose internal ionizing radiation potentially may cause prostate cancer. Pathology & Oncology Research, Vol 5, Nr 1, 28-31, 1999

Key words: prostate, PIN, BPH, apoptosis, ionizing radiation

Received: Jan 25, 1999; accepted: Feb 10, 1999
Correspondence: Béla SZENDE, First Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllôi út 26. Budapest H1085, Hungary; Tel: +36-1-2660451, Fax: +36-1-3171074; E-mail:

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