PATHOLOGY & ONCOLOGY RESEARCHVol. 7 No. 1, 2001

 Article

HLA-DRB 1 Alleles and the Susceptibility of Iranian Patients with Breast Cancer

A A GHADERI1, A TALEI2, B GHARESI-FARD1, F H FARJADIAN1, A AMIRZARGAR1, M VASEI3

1Department of Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

 

Breast cancer is considered a major malignancy among women worldwide. The contribution of genetic elements to the onset of familial breast cancer has already been established. The current study investigate the alfele frequency of HLA-DRB 1 in 36 primary operable female breast cancer patients from southern Iran by polymerase chain reaction using sequence specific primers (PCR-SSP). Results were compared with those of 36 female control subjects. Statistical analysis was performed and P values were determined for each character. Our results indicated that the frequency of HLA-DRB 1*12 allele is significantly higher in the patient group (p<0.03) compared to the control group. In addition, HLA-DRB1*11 appeared to be as the most frequent allele in the control group (29.2%) and had approximately the same distribution among the patient group (22.5%). Pathology & Oncology Research, Vol 7, Nr 1, 39-41, 2001

Key words: breast cancer; HLA-DRB1; PCR-SSP


Received: Jul 10, 2000; accepted: Jan 10, 2001
Correspondence: A A GHADERI, Department of Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz , Iran, Fax: 98-71-334589; E-mail: immunol@sums.ac.ir

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