PATHOLOGY & ONCOLOGY RESEARCHVol. 7 No. 1, 2001

 Report

Poorly Differentiated Synovial Sarcoma

A Case Report

Francesco CAPPELLO1, M BELLAFIORE2, F BUCCHIERI3, G BALSANO4, A PALMA2, G ZUMMO2

1Institute of Pathological Anatomy, University of Palermo, Palermo, Italy
2Institute of Human Anatomy, University of Palermo, Palermo, Italy
3Institute of Internal Medicine and Pneumology, Ospedale v. Cervello, Palermo, Italy
4Institute of General and Endoscopic Surgery, University of Palermo, Palermo, Italy

 

Poorly differentiated synovial sarcoma is a rare soft tissue tumor. We studied a case arising in the pleural cavity of a young subject, characterised by the presence of spindle cell, small cell, and large epithelioid cell areas. We performed stains for mucosubstances and analysed the expression of cytokeratins 5/6, 7, 8, 18, 19, CEA, CD34, Ber-Ep4 and calretinin to characterize the phenotype of this neoplasm. We furthermore assessed immunohistochemically the presence of p53, Bcl-2, Bax and caspase 3, four apoptotic markers, to evaluate a relationship between apoptotic activity and the behaviour of this tumor. Our findings showed a strong presence of calretinin, p53 and Bcl-2 in all three areas. The possibility that poorly differentiated synovial sarcoma could be calretinin-positive was a new data, to our knowledge, and it could be of some importance in diagnostic pathology. Moreover, the negligible positivity for Bax and caspase 3 suggested that the minor role of programmed cell death could be one of the causes of the aggressive behaviour of this tumor. These data also suggest that the reduction of apoptotic phenomena in poorly differentiated synovial sarcoma could be considered one of the major mechanisms of tumoral growth. Pathology & Oncology Research, Vol 7, Nr 1, 63-66, 2001

Key words: synovial sarcoma; poorly differentiated synovial sarcoma; soft tissue tumors; calretinin; apoptosis


Received: Jul 12, 2000; accepted: Jan 21, 2001
Correspondence: Francesco CAPPELLO, Institute of Pathological Anatomy, University of Palermo, Via Alla Falconara 120 Palermo 90136, Italy; Tel: +39-0339-5675268, Fax: +39-091-6553508; E-mail: FRANCAPP@HOTMAIL.COM

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