Angiogenesis-Dependent Diseases and Angiogenesis Therapy

József TÍMÁR1, Balázs DÖME2, Károly FAZEKAS1, Ágnes JANOVICS1, Sándor PAKU2

1Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
21st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary


The discovery of the molecular mechanisms of physiological vasculogenesis and pathological angiogenesis helped to recognize two classes of diseases: one where the therapeutic angiogenesis can repair the tissue damages (arteriosclerosis, myocardial infarction, limb ischemia) and the other one where inhibition of pathological angiogenesis can cure the disease or delay its progression (retinopathies, benign and malignant angiogenic tumors, progression of malignant tumors). Although there are an exponentially growing number of new synthetic molecules characterized mainly by antiangiogenic properties, the discovery of a large battery of natural pro- and anti-angiogenic factors suggests that this may provide a more physiological approach to treat both class of angiogenesis-dependent diseases in the near future. Pathology & Oncology Research, Vol 7, Nr 2, 85-94, 2001

Key words: angiogenesis; diseases; pro-angiogenesis; anti-angiogenesis

Received: Apr 16, 2001; accepted: May 28, 2001
Correspondence: József TÍMÁR, Department of Tumor Progression, National Institute of Oncology, Ráth Gy. U. 7-9. Budapest H1122, Hungary; Tel: 36 1 224 8786, Fax: 36 1 224 8620; E-mail:

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