Leiomyosarcoma of the Female Breast

Eszter SZÉKELY1, L MADARAS1, Janina KULKA1, Balázs JÁRAY1, Lajos NAGY2

12nd Department of Pathology, Semmelweis University, Budapest, Hungary
23rd Department of Surgery, Semmelweis University, Budapest, Hungary


Leiomyosarcomas of the breast are rare tumors. Less than 15 such cases have been reported in the literature so far. In this paper authors describe a case of leiomyosarcoma of a female breast presenting as a firm lobulated mass, mimicking a phylloid tumor radiographically. By fine needle aspiration biopsy, on the smears discohesive malignant looking cells were conclusive to a poorly differentiated invasive ductal carcinoma of the breast. The mastectomy specimen contained a lobulated mass, microscopically showing a partly epithelioid spindle cell tumor, immunoreactive for vimentin, desmin, smooth muscle actin antibodies, and negative for epithelial markers, hormone and growth factor receptors. Axillary lymph nodes were free of tumor. A primary leiomyosarcoma of the breast was diagnosed. Pathology & Oncology Research, Vol 7, Nr 2, 151-153, 2001

Key words: breast tumors; leiomyosarcoma

Received: Apr 27, 2001; accepted: May 28, 2001
Correspondence: Eszter SZÉKELY, 2nd Department of Pathology, Semmelweis University, Üllôi út 93 Budapest H-1091, Hungary; Tel: 36-1-218-28-80, Fax: 36-1-215-69-21; E-mail:

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