PATHOLOGY & ONCOLOGY RESEARCHVol. 7 No. 3, 2001

 Article

Relationship Between Apoptosis Regulator Proteins (bcl-2 and p53) and Gleason Score in Prostate Cancer

Semra KARABURUN PAKER1, Bahar KILICARSLAN1, Akif M CIFTCIOGLU1, Sevim OZTEKIN1, Figen C SARGIN1, Tibet ERDOGRU2, Mehmet BAYKARA2

1Department of Pathology, Akdeniz University, The Faculty of Medicine, Antalya, Turkey
2Department of Urology, Akdeniz University, The Faculty of Medicine, Antalya, Turkey

 

Cellular proliferation programmed cell death (apoptosis) are associated with tumor growth in general, and prostate cancer growth in particular. The aim of this study was to examine the expression of the apoptosis regulating genes bcl-2 and p53 and Gleason score in core needle biopsy specimens of prostate cancer using immunohistochemistry. We studied bcl-2 and p53 expression in 12 cases of low grade (Gleason score 2-5), 12 cases of intermediate grade (Gleason score 6-7) and 8 cases of high grade (Gleason score 8-10) prostate cancer. Overexpression of bcl-2 was noted in 3 of 32 patients (9.32%). One of them was high grade; others were intermediate grades. Expression of p53 was observed in 3 of low grades; others were high grade. The statistical analysis of present data suggest that there is no significant relation between p53 and bcl-2 expression and Gleason score in prostate cancer. Pathology & Oncology Research, Vol 7, Nr 3, 209-212, 2001

Key words: p53; bcl-2; prostate cancer; apoptosis


Received: Apr 6, 2001; accepted: Aug 10, 2001
Correspondence: Bahar KILICARSLAN, Department of Pathology, Akdeniz University, The Faculty of Medicine, Antalya , Turkey; Tel: +90 242 2274488, Fax: +90 242 2274482; E-mail: bkilicarslan@hotmail.com

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