A New Rapid Technique for the Fixation of Thyroid Gland Surgical Specimens

Lea RATH-WOLFSON1, Rumelia KOREN1, Eitan YANIV3, Rima SADOV2, Rivka GAL1

1Campus Golda, Department of Pathology, Hasharon Hospital, Tel Aviv, Israel
2Campus Golda, Department of Otolaryngology, Hasharon Hospital, Tel Aviv, Israel
3Campus Beilision, Department of Otolaryngology, Rabin Medical Center, Petah Tikva and Sakler Faculty of Medicine, Tel Aviv, Israel


One of the main diagnostic problems in thyroid pathology is to distinguish between follicular adenoma and follicular carcinoma. Thorough sampling of the nodule's capsule is recommended in order to identify capsular ínvasion. However, during the hardening of the tissue, by the usual fixatives the capsule shrinks and rolls downwards and sometimes the capsule separates from the remaining tissue. The present work evaluates the use of ''Lymph Node Revealing Solution'' (LNRS) for the rapid fixation (2h) of different thyroid lesions as compared to that of formalin. Fifty-one unselected consecutive cases of thyroid nodules, which included various benign and malignant lesions, were examined. Each specimen was cut in two equal parts; one was fixed in LNRS, the other in formalin. Fixation in LNRS for 2 hours gave adequate results in sectioning and staining of the tissue, and excellent immunostains. Its advantage over formalin is the conservation of the natural relationship between the capsule and the rest of the tissue, on the same plane, as well as the short time required for the final diagnosis. Pathology & Oncology Research, Vol 5, Nr 1, 70-72, 1999

Key words: lymph node reveling solution, thyroid, fixation

Received: Oct 26, 1998; accepted: Jan 21, 1999
Correspondence: Rumelia KOREN, Campus Golda, Department of Pathology, Hasharon Hospital, Tel Aviv , Israel, Fax: 972-3-9372349

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