Human Herpesvirus 8 in Hematologic DiseasesFNT1

Gábor MIKALA1, Jiuru XIE2, György BERENCSI2, Csongor KISS3, Ildikó MÁRTON4, Gyula DOMJÁN1, István VÁLYI-NAGY1

1First Department of Internal Medicine, Imre Haynal University of Health Sciences, Budapest, Hungary
2Béla Johan National Center for Epidemiology, Budapest, Hungary
3Department of Pediatrics, University Medical School of Debrecen, Debrecen, Hungary
4Department of Stomatology, University Medical School of Debrecen, Debrecen, Hungary


Human herpesvirus type 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV) is a new member of the gamma-herpesvirus family. It is an unusual herpesvirus in that it carries a large number of genes that encode oncoproteins or cell signaling proteins. In addition to being the causative agent of both HIV-associated and non-HIV-associated Kaposi's sarcoma this DNA tumor virus has been implicated in the pathogenesis of several diseases. These include multiple myeloma (MM), Waldenström's macroglobulinemia (WM), multicentric Castleman's disease (MCD), body cavity-based lymphoma (BCBL), and various other conditions such as sarcoidosis and pemphigus. While the causative role of the viral infection is fairly certain in the development of BCBL and multicentric Castleman's disease, HHV-8 may act through a different mechanism to induce plasma cell malignancies. It has been suggested - though the finding is still controversial - that infection of bone marrow stromal dendritic cells by HHV-8 might be a key factor in the etiology and pathogenesis of monoclonal gammopathies. The aim of this review is to provide a short introduction into the tumorigenic potential of HHV-8 as well as to detail the available data and possible mechanisms on the involvement of this virus in different hematologic diseases. Pathology & Oncology Research, Vol 5, Nr 1, 73-79, 1999

Key words: HHV-8, tumorigenesis

Received: Nov 14, 1998; accepted: Jan 5, 1999
Correspondence: István VÁLYI-NAGY, First Department of Internal Medicine, Imre Haynal University of Health Sciences, Szabolcs u. 35. Budapest H-1135, Hungary; Tel: +36-1-329-4630, Fax: +36-1-329-1206

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