PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 1, 1999

 Report

Primary Endometrioid Carcinoma of Fallopian tube

Clinicomorphologic Study

Jerzy RABCZYNSKY, Piotr ZIOLKOWSKI

Department of Pathology, Medical University of Wroclaw, Wroclaw, Poland

 

Twenty cases of primary Fallopian tube endometrioid carcinoma (PFTEC) are presented in the paper. This accounts for 42.5% of all histologic forms of primary Fallopian tube carcinoma (PFTC) found in our Department. The youngest patient was 38, and the oldest 68 years (mean: 56 years). Seven patients were nulliparas. Only two cases were bilateral. According to FIGO staging, 13 cases were evaluated as stage I, 4 as II, and 3 as stage III. Due to the histologic grading, 8 tumors were classified as well, 7 as moderately, and 5 as poorly differentiated. In the time of preparation of the manuscript, 12 women were still alive, 2 of them with recurrent disease. The follow-up of patients without recurrence ranged from 4 to 120 months (median: 63). Eight patients had died (survival time: from 4 to 65 months; median: 26). Metastases were found in 8 patients, especially to ovaries. In 14/20 cases of PFTEC various forms of tubal wall invasion were observed. Blood or lymphatic vessels involvement was found in 9 patients. Six out of them had died and one is alive with the symptoms of disease. Immunohistochemical detection of the mutant form of p53 protein and oncogene product, c-erbB-2, was studied in 17 cases. Nine patients exhibited simultaneous p53 protein accumulation and c-erbB-2 expression. 2/9 of these patients are alive with recurrent tumors and 4/9 died. Endometrioid carcinoma of the Fallopian tube can be characterized by a tendency to superficial invasion of tubal wall and in a half of the cases by invasion of vessels. The majority of these tumors were diagnosed at an early stage tumors. Pathology & Oncology Research, Vol 5, Nr 1, 61-66, 1999

Key words: Fallopian tube carcinoma, endometrioid carcinoma, histology, immunohistology, p53 protein, c-erbB-2


Received: Nov 1, 1998; accepted: Jan 5, 1999
Correspondence: Piotr ZIOLKOWSKI, Department of Pathology, Medical University of Wroclaw, ul. Marcinkowskiego 1 Wroclaw 50-386, Poland; Tel: 4871-209974, Fax: 4871-3281029

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