PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 2, 1999

 Article

Expression of c-erbB-2 Oncoprotein in Gastric Carcinoma: Correlation with Histopathologic Characteristics and Analysis of Ki-67

Ayse DURSUN, Aylar POYRAZ, Betül CELIK, Gülen AKYOL

Department of Pathology, Gazi University Medical School Besevler, Ankara, Turkey

 

Amplification and overexpression of the c-erbB-2 gene has been demonstrated in several tumors and thought to be important determinants of biologic behaviors of carcinomas. In this study, correlation between c-erbB-2 expression und histopathologic parameters, including proliferative activity of gastric carcinomas was evaluated. Paraffin-embedded tissue sections from 62 patients who underwent curative resection of gastric carcinoma were analyzed immunohistochemically for the expression of c-erbB-2 and Ki-67. Strong membrane staining for c-erbB-2 was detected in 11 of 62 gastric carcinomas (17,7%) and no positive reaction was evident in noncancerous tissue. The incidence of c-erbB-2 pos- itivity in intestinal type carcinomas (24,3%) washigher than that of diffuse type carcinomas (4,76%). Positive staining for c-erbB-2 was present in one of the 9 (11,1%) early gastric carcinomas and 10 of 53 (18,8%) advanced gastric carcinomas. However, no statistically significant relationships were found between c-erbB-2 expression and histopathologic type, depth on invasion, the tumor size or lymph node metastases. Among the metastatic lymph nodes, 3 were positively stained with c-erbB-2 whereas the primary tumors of two cases had been found to be negative. Additionally, no correlation was found between c-erbB-2 reactivity and proliferative activity of carcinoma cells. The results suggest that expression of c-erbB-2 protein may occur selectively in intestinal type of gastric carcinomas. However, c-erbB-2 expression is not a reliable marker of malignant potential in gastric carcinomas. Pathology & Oncology Research, Vol 5, Nr 2, 104-106, 1999

Key words: c-erbB-2; Ki-67; gastric carcinomas


Received: Dec 22, 1998; accepted: Jan 18, 1999
Correspondence: Ayse DURSUN, Department of Pathology, Gazi University Medical School Besevler, Turgut Reis Caddesi 16/8, Mebusevleri Tandogan Ankara 06580, Turkey; Tel: +90 312 2137494, Fax: +90 312 2129908

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