Burkitt's Lymphoma Variant of Post-transplant Lymphoproliferative Disease (PTLD)

Melissa A PASQUALE1, Debbie WEPPLER2, Jon SMITH1, Michael ICARDI1, Alexandra AMADOR1, Monica GONZALEZ2, Tomoaki KATO2, Andreas TZAKIS2, Phillip RUIZ1

1Department of Pathology, University of Miami, Miami, USA
2Department of Surgery, University of Miami, Miami, USA


The occurrence of posttransplant lymphoproliferative disorder (PTLD) in solid organ allograft recipients can be quite varied in clinical presentation, histopathological characteristics and frequency. A variety of lymphomas can develop as a PTLD although some types appear infrequently and remain poorly understood in this clinical setting. In this report, we describe two cases of Burkitt’s lymphoma presenting as a PTLD following liver transplantation. The recipients were 12 and 44 years of age and displayed gastrointestinal involvement by the tumors several years following transplant. The tumors displayed the typical histological features of Burkitt’s lymphoma and were markedly positive for EBV. The tumors displayed similar immunophenotypic characteristics by flow cytometry and had rearrangements of the immunoglobulin J-H heavy chain. The tumors required aggressive chemotherapy and a cessation of immunosuppressive therapy. This report demonstrates that Burkitt’s type lymphomas can develop in the posttransplant setting and that these tumors contain morphologic, cytofluorographic and molecular features identical to Burkitt’s lymphomas that occur in non-transplant patients. Our experience is that these PTLD- Burkitt’s lymphomas behave aggressively and require intensive chemotherapeutic intervention. Pathology & Oncology Research, Vol 8, Nr 2, 105-108, 2002

Key words: PTLD; Burkitt’s lymphoma

Received: Feb 14, 2002; accepted: Apr 8, 2002
Correspondence: Phillip RUIZ, Department of Pathology, University of Miami, Jackson Memorial Hospital - Holtz Center, Room 2101 Miami 33136, USA; Tel: 305-585-7344, Fax: 305-324-0149; E-mail:

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