PATHOLOGY & ONCOLOGY RESEARCHVol. 8 No. 2, 2002

 Article

Down Regulation of Endothelial Adhesion Molecules in Node Positive Breast Cancer: Possible Failure of Host Defence Mechanism

Maya MADHAVAN1, Priya SRINIVAS1, Elizabeth ABRAHAM2, Iqbal AHMED3, N R VIJAYALEKSHMI4, Prabha BALARAM1

1Division of Cancer Research, Regional Cancer Centre, Trivandrum, India
2Division of Histopathology, Regional Cancer Centre, Trivandrum, India
3Division of Surgical Oncology, Regional Cancer Centre, Trivandrum, India
4Department of Biochemistry, University of Kerala, Trivandrum, India

 

Endothelial cell adhesion molecules (CAMs) are important in tumorigenesis and host defense mechanism. Their status in breast cancer with regard to nodal invasion is not yet known. Hence we looked at the expression of three important CAMs: VCAM, ICAM and E-selectin. A downregulation of all these CAMs was noted in node positive breast cancer in comparison to node negative cases. This suggests shedding of these molecules in cases with nodal metastasis which might help the tumor cells to escape the host defense mechanism. On multi-variate analysis, VCAM alone emerged as an independent predictor of nodal metastasis. Pathology & Oncology Research, Vol 8, Nr 2, 125-128, 2002

Key words: VCAM; ICAM; E-selectin; invasion; breast cancer


Received: Mar 20, 2002; accepted: May 25, 2002
Correspondence: , Division of Cancer Research, Regional Cancer Centre, Trivandrum 695011, India; Tel: 91-0471-522203, Fax: 91-0471-447454; E-mail: rcctvm@md2.vsnl.net.in

Click here to get the full-text version in PDF!
ad