Central Neurocytoma with Malignant Course

Neuronal and Glial Differentiation and Craniospinal Dissemination

Gábor ELEK1, Felicia SLOWIK2, Lóránd ERÔSS3, Szabolcs TÓTH3, Zerind SZABÓ3, Katalin BÁLINT2

1Departments of Pathology, Hospital of Hungarian Railways, Budapest, Hungary
2Pathology, National Institute of Neurosurgery, Budapest, Hungary
3Department of Neurosurgery and Dr Tóth Zoltán Foundation, Hospital of Hungarian Railways, Budapest, Hungary


Central neurocytoma is a benign neuronal tumor of young adults in the lateral cerebral ventricles with characteristic X ray and light microscopic findings. In many respects typical central neurocytoma is reported below, with recurrence in the third month requiring reoperation. Death ensued in the fifth postoperative month. Subsequent histology proved progressive vascular proliferation and increasing, unusual glial differentiation of the neuronal tumor. At autopsy tumorous seeding blocked the liquor circulation. A thin tumorous layer covered the surface of all ventricles, the cerebellum and medulla oblongata. The GFAP positive cells out-numbered the synaptophysin positive ones. Increase of GFAP positivity and vascular proliferation of the central neurocytoma may be alarming signs suggesting a malignant course in addition to the other atypical features. Pathology & Oncology Research, Vol 5, Nr 2, 155-159, 1999

Key words: central neurocytoma; atypical central neurocytoma; glial and neuronal differentiation; ganglioglioma

Received: Dec 7, 1998; accepted: Mar 18, 1999
Correspondence: Gábor ELEK, Departments of Pathology, Hospital of Hungarian Railways, Pathology of MÁV Hospital at Pest, Podmaniczky u 11 Budapest H-1062, Hungary

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