Sarcomatoid Renal Cell Carcinoma with Foci of Chromophobe Carcinoma

Gábor CSERNI1, Beáta Rita KOVÁCS3, Miklós TARJÁN1, Zoltán SÁPI3, Zsolt DOMJÁN2, Zoltán SZABÓ2

1Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
2Department of Urology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
3Department of Pathology, St. John's Hospital, Budapest, Hungary


Both chromophobe carcinoma and sarcomatoid carcinoma of the kidney are rare. The former is characterized by a relatively good prognosis, while the latter is a highly aggressive tumor. Coexistence of the two components in one renal tumor, which has been reported only rarely, is therefore paradoxical. Both sarcomatoid and chromophobe renal carcinoma were diagnosed in a 52-year-old woman following nephrectomy and resection of metastases in the right lobe of the liver. She died of the disease two months after the first operation; only the sarcomatoid component of her tumor was seen in the liver metastasis and the recurrent carcinoma. Differences in phenotype, immunophenotype and DNA-ploidy patterns of the two components are reported. The intensive p53 staining observed only in the sarcomatoid area supports the role of the TP53 gene in the transformation of chromophobe renal carcinoma to sarcomatoid carcinoma. Pathology & Oncology Research, Vol 8, Nr 2, 142-144, 2002

Key words: chromophobe renal cell carcinoma; sarcomatoid renal carcinoma; DNA-ploidy; p53

Received: Apr 3, 2002; accepted: May 20, 2002
Correspondence: Gábor CSERNI, , ,

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