PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 2, 1999

 Article

HLA Antigens in Iranian Patients with B-cell Chronic Lymphocytic Leukemia

Seyed M MOAZZENI1, Ali A AMIRZARGAR3, Fazel SHOKRI2

1Department of Immunology, School of Medical Sciences, Tarbiat Modarres University,, Tehran, Iran
2Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3Department of Immunology, Ahwaz University of Medical Sciences, Ahwaz, Iran

 

The frequency of HLA class-I and class-II antigens was investigated in 32 Iranian patients with B-cell chronic lymphocytic leukemia (B-CLL), using the microlymphocytotoxicity method. A significant increase in the HLA-B13 (P<0.01) and DR53 (P < 0.05) and a significant negative association with the A11 (P < 0.05), B35 (P < 0.05), Cw3 (P < 0.05), and DR1 (P < 0.02) antigens were observed in these patients, compared to the control normal population. These results suggest involvement of some HLA antigens in the multifactorial process of predisposition to B-CLL. Pathology & Oncology Research, Vol 5, Nr 2, 142-145, 1999

Key words: HLA antigens; chronic lymphocytic leukemia


Received: Mar 10, 1999; accepted: Apr 15, 1999
Correspondence: Fazel SHOKRI, Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran , Iran; Tel: +98 21 8853021 (1), Fax: +98 21 6462267

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