PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 2, 1999

 Article

Magnetic Resonance Imaging of Bone Marrow Versus Bone Marrow Biopsy in Malignant Lymphoma

Mustafa ÖZGÜROGLU1, Gül Esen ERSAVASTI2, Gökhan DEMIR1, Hilal AKI3, Fuat DEMIRELLI1, Kaya KANBEROGLU2, Nil MANDEL1, Evin BÜYÜKÜNAL1, Süheyla SERDENGEÇTI1, Bülent BERKARDA1

1Medical Oncology Section, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
2Department of Radiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
3Department of Pathology, Cerrahpasa Medical School, Istanbul, Turkey

 

Bone marrow involvement is a frequent finding in malignant lymphoma. Bone marrow biopsy of the posterior iliac crest is routinely performed for staging. Abnormal magnetic resonance imaging (MRI) signals of bone marrow was also reported to be indicative of bone marrow involvement. This study included 60 patients with malignant lymphoma. Unilateral bone marrow biopsy of the posterior iliac crest was performed. MRI of lumbar spine was studied within 24 hours of bone marrow biopsy. 22 healthy controls were used for the detection of MRI objectivity during visual evaluation. In 83% of patients (50/60), biopsy and MRI results agreed completely. In two patients, histologic sections failed to show any evidence of bone marrow involvement despite abnormal MRI signals suggestive of involvement. In three patients, MRI was completely normal despite biopsy proven bone marrow infiltration. False negativity (3/60) and false positivity (2/60) rates were very low. Negative biopsy findings with positive or equivocal MRI results should not exclude bone marrow involvement and needs further evaluation with bilateral or guided biopsy. Thus, we conclude that MRI of bone marrow is a fairly sensitive, noninvasive modality and might be of potential value in detecting bone marrow infiltration in malignant lymphoid neoplasms which can be utilized as a useful adjunct to standard staging procedures. Pathology & Oncology Research, Vol 5, Nr 2, 123-128, 1999

Key words: malignant lymphoma; bone marrow biopsy; magnetic resonance imaging


Received: Feb 12, 1999; accepted: Apr 15, 1999
Correspondence: Mustafa ÖZGÜROGLU, Medical Oncology Section, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Yogurtçu Basi Sokagi, Akçira apt. 20/3 ˆ Istanbul 81030, Turkey; Tel: +90-216-3638378, Fax: +90-212-5877700; E-mail: ozguroglu@superonline.com

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