PATHOLOGY & ONCOLOGY RESEARCHVol. 8 No. 4, 2002

 Article

The Expression of c-erbB-1 and c-erbB-2 in Iranian Patients with Gastric Carcinoma

Abbas GHADERI3, Mohammad VASEI2, S A MALECK-HOSSEINI1, Behronz GHARESI-FARD3, Maliheh KHODAMI2, Mehrnoosh DOROUDCHI3, Helmout MODJTAHEDI4

1Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
2Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran

 

To assess the significance of epidermal growth factor receptor family members, the overexpression of c-erbB-1 and c-erbB-2 was retrospectively investigated in 146 southern Iranian gastric cancer patients. Indirect immunostaining was used to evaluate the expression of these two receptors in formalin-fixed paraffin-embedded tissue samples. c-ErbB-1 expression was observed in 47 (32.2%) and c-erbB-2 expression was observed in 24 (16.4%) of tumors. Significant positive correlations were observed between c-erbB-1 expression and tumor size, local invasion, lymph node involvement and tumor stage. There was also a negative correlation between c-erbB-2 expression and tumor stage. These results may suggest the contribution of c-erbB-1 molecule in progression of gastric carcinomas in southern Iranian patients. Moreover, the relatively high percentage of c-erbB-2 positive tumors may provide a useful target for the immunotherapy of these cancers. Pathology & Oncology Research, Vol 8, Nr 4, 252-256, 2002

Key words: c-erbB-1; c-erbB-2; gastric carcinoma; southern Iranian


Received: Sep 4, 2002; accepted: Dec 10, 2002
Correspondence: Abbas GHADERI, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz , Iran; Tel: +98-711-230 3687, Fax: +98-711-230 3687; E-mail: ghaderia@sums.ac.ir

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