PATHOLOGY & ONCOLOGY RESEARCHVol. 8 No. 4, 2002

 Report

Pulmonary Lymphomatoid Granulomatosis Evolving to Large Cell Lymphoma in the Skin

Nil CULHACI1, Edi LEVI1, Serdar SEN2, Furuzan KACAR1, Ibrahim METEOGLU1

1Department of Pathology, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey
2Department of Thoracic Surgery, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey

 

Lymphomatoid granulomatosis is an angiodestructive, angioinvasive lymphoproliferative disorder. It involves most frequently lungs, central nervous system and skin. Recent studies indicate that lymphomatoid granulomatosis is an Epstein-Barr virus associated B cell disorder with a background of reactive T lymphocytes. In a 49 year old woman presenting with fever, malaise and pulmonary masses the diagnosis of lymphomatoid granulomatosis was established histologically by open lung biopsy. Following the initial diagnosis the patient was found to have gastric and skin involvement. The skin lesion was diagnosed as diffuse large B-cell lymphoma. Pathology & Oncology Research, Vol 8, Nr 4, 280-282, 2002

Key words: lymphomatoid granulomatosis; Epstein-Barr virus; large cell lymphoma; angiocentric lymphoma


Received: Oct 29, 2002; accepted: Dec 10, 2002
Correspondence: Nil CULHACI, Department of Pathology, Adnan Menderes University, Faculty of Medicine, Aydin 09100, Turkey; Tel: 90 02562120145 / 227, Fax: 90 0256 2120146; E-mail: nculhaci@hotmail.com

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