PATHOLOGY & ONCOLOGY RESEARCHVol. 9 No. 1, 2003

 Article

Diabetes Mellitus and Bladder Cancer - An Epidemiological Relationship?

Yeung NG1, I HUSAIN2, N WATERFALL2

1Department of Surgery and Molecular Oncology, University of Dundee, Dundee, UK
2Bedford General Hospital, Bedford, UK

 

An epidemiological association between diabetes mellitus and transitional cell carcinoma of the bladder has been proposed. This study looked retrospectively at 125 patients with transitional cell carcinoma of the bladder as a study group and 80 other hospital patients with conditions not specifically associated with diabetes mellitus as a control group. Diabetic patients had an increased, significant odds ratio for bladder cancer compared with non diabetics even after adjustment for smoking and age [OR: 2.69 p=0.049 (95% CI 1.006-7.194)] A history of smoking OR 2.16 p=0.013 (95% C.I. 1.175-3.964) is a significant independent association with transitional cell carcinoma of the bladder as is age: p=0.001 OR 1.07. We propose potential pathogenic pathways for transitional cell carcinoma of the bladder in diabetic patients based on altered integrin and cadherin distribution in urothelial cells in diabetic patients. A larger study is planned to confirm an association between diabetes mellitus and transitional cell carcinoma of the bladder. Pathology & Oncology Research, Vol 9, Nr 1, 30-31, 2003


Received: Sep 23, 2002; accepted: Feb 8, 2003
Correspondence: Yeung NG, Department of Surgery and Molecular Oncology, University of Dundee, Dundee , UK; Tel: 00-44-1382-632567; E-mail: y.ng@dundee.ac.uk

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