Molecular Pathology of Tumor Metastasis III.

Target array and combinatorial therapies

József TÍMÁR1, Andrea LADÁNYI1, István PETÁK2, András JENEY2, László KOPPER2

1Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
21st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary


Therapy of tumor progression and the metastatic disease is the biggest challenge of clinical oncology. Discovery of the diverse molecular pathways behind this complex disease outlined an approach to better treatment strategies. The development of combined cytotoxic treatment protocols has produced promising results but no breakthrough in the clinical management of metastatic disease. The multiple - specific and non-specific pathways and cellular targets of tumor progression are outlined in this review. Such an approach, individually designed for various cancer types, may have a better chance to treat or even cure cancer patients with progressive disease. Pathology & Oncology Research, Vol 9, Nr 1, 49-72, 2003

Key words: metastasis therapy; molecular target; cancer cell; host cell

Received: Feb 24, 2003; accepted: Mar 22, 2003
Correspondence: József TÍMÁR, Department of Tumor Progression, National Institute of Oncology, Ráth György u. 7-9 Budapest 1122, Hungary; Tel: 36-1-224-8786, Fax: 36-1-224-8706; E-mail:

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