Trace Elements Improve Survival of DTIC-Treated Mice with Overt Liver Metastases of Lewis Lung Carcinoma

Erzsébet RÁSÓ1, Sándor PAKU2, László KOPPER2, József TÍMÁR1

1National Institute of Oncology, Budapest, Hungary
21st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary


Trace elements have been previously shown to have specific antimetastatic effects in a mouse 3LLHH liver metastasis model. Here we have analyzed the effect on the survival of animals with liver metastases. Trace elements administered per os at 500-5000 mg/kg/day did not affect the survival of animals with liver metastases. However, when trace element treatment was combined with dacarbazine (DTIC) administration, the survival of animals was significantly improved (55%). This effect was specific for DTIC since trace elements did not influence the effect of 5-fluorouracil on survival in this liver metastasis model. These data and those found in the literature all suggest that trace elements can specifically modulate the antitumoral/antimetastatic effects of chemotherapeutic agents. Pathology & Oncology Research, Vol 9, Nr 2, 96-99, 2003

Key words: 3LL-HH tumor; mice; trace element mixture; liver metastasis; survival; 5-FU; DTIC

Received: Apr 10, 2003; accepted: May 25, 2003
Correspondence: József TÍMÁR, National Institute of Oncology, Department of Tumor Progression, Ráth György 7-9 Budapest H-1122, Hungary; Tel: 36-1-224-8786, Fax: 36-1-224-8706; E-mail:

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