PATHOLOGY & ONCOLOGY RESEARCHVol. 10 No. 1, 2004

 Review

Clinical Manifestations of Genetic Instability Overlap One Another

Károly MÉHES, György KOSZTOLÁNYI

Research Group of Clinical Genetics of the Hungarian Academy of Sciences, Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary

 

Cancer syndromes are characteristic associations of specific malignancies with various congenital anomalies. In addition to such diseases, an increased prevalence in general of chromosomal instability, malformations, immunodeficiencies, altered growth and development, and reproductive loss has been observed in both childhood leukemias and solid tumors. The overlap among these congenital disorders suggests their common prenatal, possibly genetic origin and thus the existence of a nonspecific genetic instability leading to various clinical manifestations of disturbancies in cell division. Seeking for related features in family members of a patient with malignancy may be of clinical value in detecting predisposition to cancer. Pathology & Oncology Research, Vol 10, Nr 1, 12-16, 2004

Key words: genetic instability; cancer-prone diseases; mild errors of morphogenesis; premature centromere division; predisposition to cancer


Received: Oct 30, 2003; accepted: Dec 10, 2003
Correspondence: Károly MÉHES, Research Group of Clinical Genetics of the Hungarian Academy of Sciences, Department of Medical Genetics and Child Development, University of Pécs, József Attila u. 7 Pécs H-7623, Hungary; Tel: (+36) 72-536 478, Fax: (+36) 74-535-972; E-mail: karoly.mehes@aok.pte.hu

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