Follicular Dendritic Reticulum Cell Tumor Mimicking Inflammatory Pseudotumor of the Spleen

Ferenc BRITTIG1, Elvira AJTAY2, Pál JAKSÓ3, Gábor KELÉNYI3

1Department of Pathology, County Hospital, Veszprém, Hungary
2Department of Internal Medicine, County Hospital, Veszprém, Hungary
3Department of Pathology, University of Pécs, Faculty of Medicine, Pécs, Hungary


In the course of a routine clinical check up of the 54 year old male a splenic well circumscribed tumor like mass of 12 cm in diameter was discovered. Splenectomy with removal of splenic hilar lymph nodes and liver wedge biopsy were performed. Four years later the patient is symptom free. In the removed spleen the tumor like lesion showed a pattern consistent with the diagnosis of inflammatory pseudotumor. However, besides lymphocytes, plasma cells, macrophages, eosinophils and myofibroblasts a high number of slightly polymorphic, frequently binucleated cells positive for CD21 and CD23 were seen. These cells which were scattered or formed smaller or larger groups and fascicles were considered to represent follicular dendritic reticulum cells (FDRCs) and the lesion a FDRC tumor. Flow cytometric DNA ploidy analysis showed a hyperdiploid cell population inside the tumor like lesion. Besides FDRC tumors of high and of intermediate malignancy the present case may represent a low grade type of moderate proliferation activity. The FDRCs of the lesion and a few smaller spindle cells were EBER positive indicative of the presence of EBV. No EBER positive cells were seen in the uninvolved spleen. Pathology & Oncology Research, Vol 10, Nr 1, 57-60, 2004

Key words: Follicular dendritic reticulum cells

Received: Oct 30, 2003; accepted: Jan 20, 2004
Correspondence: Gábor KELÉNYI, Department of Pathology, University of Pécs, Faculty of Medicine, Szigeti út 12. Pécs H-7624, Hungary

Click here to get the full-text version in PDF!