Studies on the Antibodies to Human Herpesvirus Type 6 Among Hungarian Patients with Asymptomatic HIV Infection

Csaba László MARÓDI1, Anna CSISZÁR1, Beatriz SIERRA-VAZQUEZ1, Dario DI LUCA2, Éva BARABÁS3, Károly NAGY3, Joseph ONGRÁDI1

1Institute of Microbiology, Semmelweis University of Medicine, Budapest, Hungary
2Institute of Microbiology, University of Ferrara, Ferrara, Italy
3National Institute of Dermato-Venereology, Budapest, Hungary


The occurrence and the possible role in promoting HIV infection by human herpesvirus type 6 (HHV-6) have not yet been revealed in Hungary. In different groups of patients, serum titre of IgM and IgG antibodies, as well as avidity of IgG were quantitated by indirect immunofluorescence and an enzyme-linked immunosorbent assay, using isolate U1102 of HHV-6 variant A as antigen. In 60% of HIV-seronegative adult controls, high avidity IgG antibodies were found in low titre suggesting childhood infection. In HIV-seronegative persons with high risk behaviour for HIV-infection, both IgM and low avidity IgG were frequently found in higher titre, representing either primary or frequent reinfections, or reactivation of latent HHV-6. In asymptomatic HIV-seropositive patients, high titre of high avidity IgG antibodies was predominant, proving virus infection in the near past. These results indicate the contribution of HHV-6 to immunosuppression prior to AIDS, predisposing the organism to HIV infection. Pathology & Oncology Research, Vol 4, Nr 1, 56-61, 1998

Key words: HHV-6; seroepidemiology; IgM; IgG avidity; asymptomatic HIV-1 infection

Received: Nov 17, 1997; accepted: Jan 22, 1998
Correspondence: Joseph ONGRÁDI, National Institute of Dermato-Venereology, , Mária u. 41. Budapest H-1085, Hungary; Tel: +361-2660465/5717, Fax: +361-2104874; E-mail:

Click here to get the full-text version in PDF!