PATHOLOGY & ONCOLOGY RESEARCHVol. 4 No. 1, 1998

 Report

Plasma HIV-1 Load and Disease Progression in HIV-Infected Patients in Hungary

Judit SEGESDI1, Ágnes GYURIS1, Dénes BÁNHEGYI2, Dalma VÖDRÖS1, Ágnes BAKOS1, János MINÁROVITS1

1Microbiological Research Group, ''Béla Johan'' National Institute of Hygiene, Budapest, Hungary
2Department of Immunology, ''Szt. László'' Hospital, Budapest, Hungary

 

Nucleic Acid Sequence Based Amplification (NASBA) is a suitable method for the quantification of HIV-1 RNA in plasma and serum samples. Since determination of the viral load appears to be a valuable marker for the prediction of disease progression and for monitoring the efficiency of antiretroviral therapy, the National AIDS Committee initiated the introduction of NASBA in Hungary at the end of 1996. We obtained plasma samples from patients with ARC and AIDS of the Szt. László Hospital, Budapest. We found an increased viral burden in untreated AIDS (CDC group C) patients compared to untreated ARC (CDC group B) patients. In plasma samples of clinically stable ARC and AIDS patients treated with antiretroviral drugs we detected relatively low HIV-1 RNA copy levels while similarly treated ARC and AIDS patients with progressive disease had high HIV-1 RNA copy numbers. The CD4+ T-cell count was lower in AIDS patients compared to ARC patients, as expected. In general, there was an inverse correlation (r = -0.487, P < 0.0001) between CD4+ T-cell counts and HIV-1 RNA levels. We concluded that measurement of HIV-1 RNA plasma level has an important role in assessing prognosis and effects of antiretroviral therapy in HIV-infected patients. Pathology & Oncology Research, Vol 4, Nr 1, 52-55, 1998

Key words: plasma HIV-1 RNA copy number; NASBA; AIDS; AIDS Related Complex


Received: Nov 17, 1997; accepted: Jan 25, 1998
Correspondence: Judit SEGESDI, Microbiological Research Group, ''Béla Johan'' National Institute of Hygiene, Pihenõ út 1. Budapest H-1529, Hungary; Tel: (36)(1)1760044, Fax: (36)(1)1760409; E-mail: sgesdi@microbi.hu

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