PATHOLOGY & ONCOLOGY RESEARCHVol. 4 No. 1, 1998

 Article

Embryotoxicity and Teratogenicity of Some Derivatives of Chloroethylaminophenylacetic Acid

Violeta ZALGEVICIENÉ, Janina ZUKIENÉ, Grazina GRAZELIENÉ, Giedre SINKEVICIÚTÉ, Janina DIDZIAPETRIENÉ

Department of the Experimental Therapy of Lithuanian Oncology Center, Faculty of Medicine of Vilnius University, Vilnius, Lithuania

 

Embryotoxic and teratogenic properties of Lophenal, Phenalon, Pharanox and Pharanoxi selenate were investigated experimentally. All examined antitumour agents showed embryotoxic effects. Lophenal, Phenalon and Pharanox had teratogenic effects. By modifying the structure of Pharanox with selenium a reduction in teratogenic effect was achieved. Pathology & Oncology Research, Vol 4, Nr 1, 27-29, 1998

Key words: embryotoxiciy; terotogenicity; antitumor agents


Received: Aug 6, 1997; accepted: Jan 22, 1998
Correspondence: Janina DIDZIAPETRIENÉ, Department of the Experimental Therapy of Lithuanian Oncology Center, Faculty of Medicine of Vilnius University, Santariskiu 1 Vilnius 2600, Lithuania

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