PATHOLOGY & ONCOLOGY RESEARCHVol. 4 No. 4, 1998

 Seminar

Diagnostics of Multidrug Resistance in Cancer

Gergely SZAKÁCS, Katalin JAKAB, Ferenc ANTAL, Balázs SARKADI

National Institute of Haematology and Immunology, Membrane Research Group of the Hungarian Academy of Sciences, Budapest, Hungary

 

Multidrug resistance (MDR), caused by the overexpression of two membrane proteins, MDR1-Pgp and/or MRP, is a major obstacle in the chemotherapy of cancer. The proper laboratory diagnosis of clinical multidrug resistance is still an unresolved question, and this uncertainty, in a vicious cycle, does not allow the correct evaluation of the clinical relevance of the MDR phenomenon. Moreover, inefficient MDR diagnostics hinders the development of effective resistance-modulation strategies. In this review, after describing the basic features of the MDR drug pump proteins, the currently employed diagnostic methods are discussed. We suggest that a quantitative, functional method developed in our laboratory may provide a major help in the laboratory assessment of cancer MDR. Pathology & Oncology Research, Vol 4, Nr 4, 251-257, 1998

Key words: P-glycoprotein; MDR1; MRP; multidrug transporters; diagnostic methods


Received: Oct 30, 1998; accepted: Nov 20, 1998
Correspondence: Balázs SARKADI, National Institute of Haematology and Immunology, Membrane Research Group of the Hungarian Academy of Sciences, Daróczi u. 24. Budapest H-1113, Hungary; Tel: +36-1-372-4353, Fax: +36-1-372-4353

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