PATHOLOGY & ONCOLOGY RESEARCHVol. 4 No. 4, 1998

 Article

Apoptosis and p53 Expression in Human Gliomas

László SIPOS1, Zsolt SZEGEDI2, Imre FEDORCSÁK1, Dénes ÁFRA1, Béla SZENDE2

1National Institute of Neurosurgery, Budapest, Hungary
2Research Unit for Molecular Pathology, Joint Research Organisation of the Hungarian Academy of Sciences and the Semmelweis University of Medicine, First Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary

 

Twenty-five human gliomas of different histological grade and type were studied for p53 expression by immunohistochemistry and for apoptosis using ApopTagTM method. p53 expression (percentage of positive cells) was highest in anaplastic astrocytomas, followed by low grade astrocytomas and surprisingly in glioblastomas. Granular cytoplasmic p53 positivity appeared in 4/5 low grade oligodendroglioma and in 2/5 low grade mixed oligoastrocytomas. The means of apoptosis index in the different tumor types ranged between 0.8 and 11.5 with the highest values in anaplastic astrocytoma and glioblastomas. Although the number of cases per group were relatively low and the individual vales showed differences it seems that p53 expression is related to the biological aggressiveness of gliomas. It is also suggested that high level of apoptosis in malignant glioma could represent a p53 independent pathway. Pathology & Oncology Research, Vol 4, Nr 4, 267-270, 1998

Key words: apoptosis; p53 expression; gliomas, grade


Received: Jun 22, 1998; accepted: Nov 10, 1998
Correspondence: Béla SZENDE, Research Unit for Molecular Pathology, Joint Research Organisation of the Hungarian Academy of Sciences and the Semmelweis University of Medicine, First Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllõi út 26. Budapest H-1085, Hungary; Tel: +36-1-2660451, Fax: +36-1-3171074; E-mail: bszende@korb1.sote.hu

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