Haptoglobin-related Protein as a Serum Marker in Malignant Lymphoma

Ron EPELBAUM1, Channa SHALITIN2, Ruth SEGAL1, Clari VALANSI2, Ida ARSELAN3, David FARAGGI3, Michelle LEVIOV1, Menahem BEN-SHAHAR1, Nissim HAIM1

1Department of Oncology, Rambam Medical Center, Haifa, Israel
2Department of Biology, Technion-Israel Intitute of Technology, Haifa, Israel
3Department of Statistics, University of Haifa, Haifa, Israel


A novel serum 21 kDa haptoglobin-related protein (Hpr) was investigated in patients with malignant lymphoma, to evaluate its correlation with clinical and histologic features at presentation and its possible role as a tumor marker for patient outcome. One hundred fifty eight serum samples were taken from 88 patients with non-Hodgkin's lymphoma (n=58) and Hodgkin's disease (n=30) at presentation and in the course of follow-up. Sera from 61 healthy volunteers served as normal controls. Serum Hpr levels in the lymphoma patients (median 430x103 u/ml, range 0-4000x103) were significantly higher than in the control group (median 68x103 u/ml, range 0-180x103) (p=0.0001). Higher median Hpr values were detected in patients with advanced disease (p=0.013), ''B'' symptoms (p=0.029) and in males (p=0.053). There was also a significant correlation between Hpr and erythrocyte sedimentation rate (p=0.028). Serial determinations showed a significant decrease of the initial Hpr values obtained after treatment in 41 patients, 38 of whom achieved complete remission. In the follow-up period additional Hpr measurements were taken from 17 patients. Three of them eventually relapsed, and showed increased Hpr levels at the time of relapse. Hpr levels remained low in 11 of 14 patients who maintained complete remission, and increased in three. In conclusion, serum Hpr is a new serum tumor marker of potential use in the clinical setting of lymphoma. Pathology & Oncology Research, Vol 4, Nr 4, 271-276, 1998

Key words: Haptoglobin-related protein; 21-kDa protein; ELISA; lymphoma

Received: Aug 12, 1998; accepted: Sep 30, 1998
Correspondence: Ron EPELBAUM, Department of Oncology, Rambam Medical Center, Haifa 31096, Israel; Tel: 972-4-8543128, Fax: 972-4-8542929

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