A Trace Element Preparation Increases Antitumor Activity in Mice

Jurij Akimovich GRINEVICH1, József BÉRES Jr2, Galina Dmitrijevna BENDYUG1

1Ukrainian Research Institute of Oncology and Radiology, Ministry of Health of Ukraine, Kiev, Ukraine
2Department of Research and Development, Béres Co. Ltd., Budapest, Hungary


A trace element preparation (Béres Drops Plus, BDP) produced immunomodulatory effects in previous in vitro and in vivo experiments. Here, C57B1/6 inbred mice were transplanted with either Lewis lung tumor or with B16 melanoma. BDP was given intraperitoneally a. before transplantation; b. after transplantation or c. after the removal of the primary tumor. As a result, BDP pretreatment could slow down the tumor progression by decreasing the number and the volume of metastases as well as the proportion of mice with metastases without influencing the growth of the primary tumors. Furthermore, BDP treatment improved the immunological activity of the tumor-bearing host, too. These preliminary data suggest that the parenteral administration of the practically non-toxic BDP could help to control tumor progression in experimental models. Pathology & Oncology Research, Vol 3, Nr 1, 34-37, 1997

Key words: trace elements; antimetastatic; immunomodulation

Received: Feb 27, 1997; accepted: Mar 25, 1997
Correspondence: Jurij Akimovich GRINEVICH, Ukrainian Research Institute of Oncology and Radiology, Ministry of Health of Ukraine, 33/43 Lomonosov St Kiev 252022, Ukraine

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