Immunologic Profile of Patients Suffering from Herpes Simplex Virus (HSV) -Associated Oral Lesions Treated with Natural Human Interferon Alpha (Egiferon)

György KÖVESI1, Katalin PÁLÓCZI2, Klára ÓNODY3, Béla FEKETE4

1Department of Maxillofacial Surgery, Semmelweis University of Medicine, Budapest, Hungary
2National Institute of Hematology and Immunology, Budapest, Hungary
3EGIS Pharmaceutical Company, Budapest, Hungary
4Teaching Hospital, Semmelweis University of Medicine, Budapest, Hungary


10 consecutive patients with HSV-associated chronic oral lesions were treated with Egiferon for ten days. There were a statistically significant increase in the Large Granule Lymphocyte (LGL) counts and the number of spontaneous E rosette forming cells by the end of the treatment period. Interferon alpha brought about a preferential expression of CD8, CD11b, CD14, CD25 and CD45RO cell surface molecules without any effect on the expression of CD2, CD3, CD4, CD20 and HLA-DR. Pathology & Oncology Research, Vol 3, Nr 1, 44-46, 1997

Key words: interferon alpha; herpes virus; lymphocyte subpopulations

Received: Mar 2, 1997; accepted: Mar 22, 1997
Correspondence: Béla FEKETE, Teaching Hospital, Semmelweis University of Medicine, Kútvölgyi út 4. Budapest 1125, Hungary; Tel: (36)(1)1569573, Fax: (36)(1)1558251

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