PATHOLOGY & ONCOLOGY RESEARCHVol. 3 No. 2, 1997

 Review

12-Lipoxygenase in Human Tumor Cells

Wolfgang HAGMANN

Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany

 

Tumor cell proliferation and metastasis proceed via a network of interdependent molecular events with a vast array of molecular players and signal transduction mechanisms differing in various types of human tumors. In the sequence of events necessary for carcinogenesis, arachidonate metabolites have been documented to play a significant role at several steps. Arachidonate metabolism in human cells occurs via several enzymatic pathways, including enzymes such as cyclo-oxygenases and lipoxygenases. This review pays particular attention to one member of the lipoxygenase family of enzymes, namely 12-lipoxygenase, since an arachidonate metabolite generated via 12-lipoxygenase action, 12(S)-HETE, has been shown to elicit various prometastatic effects of tumor cells in vivo and in vitro. We focus especially on mechanisms of activation and modulation of 12-lipoxygenase expression in human tumor cells, since various tumor cells express 12-lipoxygenase or are responsive to metabolites derived from 12-lipoxygenase action, thus offering a potential for successful therapeutic intervention against such tumors. Pathology & Oncology Research, Vol 3, Nr 2, 83-88, 1997

Key words: epidermal growth factor; 12-lipoxygenase; metastasis; nuclear translocation; tumor cells


Received: Apr 22, 1997; accepted: May 18, 1997
Correspondence: Wolfgang HAGMANN, Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280 Heidelberg D-69120, Germany; Tel: (49)6221422405, Fax: (49)6221422402; E-mail: W.Hagmann@DKFZ-Heidelberg.de

Click here to get the full-text version in PDF!
ad