Polychondritis Terminating in Eosinophilic Leukemia

Judit VÁRKONYI1, Lajos JAKAB1, Attila ZALATNAY2, Péter NAGY2, Rita VÁMOS3, Tamás SZOMBATHY1

13rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
21st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
32nd Department of Ophthalmology, Semmelweis University, Budapest, Hungary


We report here on a patient presenting with Relapsing Polychondritis (RP) two years before the diagnosis of Myelodysplasia (MDS) terminating in Eosinophilic Leukemia (EoL). The evolution of RP several years prior to the presentation of MDS does not support a paraneoplastic etiology of RP in this patient. The terminal development of EoL in our case is assumed to represent clonal evolution caused by a second mutagenic event. The existence of autoimmune skin disorders in both the patient and his offspring (vitiligo and subacute cutaneous lupus erythematosus, respectively) implies that the coexistence of MDS and RP may have been caused by a functional disturbance of the immune system. Pathology & Oncology Research, Vol 3, Nr 2, 135-138, 1997

Key words: relapsing polychondritis; vitiligo; myelodysplasia; eosinophilia; eosinophil leukemia

Received: Apr 29, 1997; accepted: May 21, 1997
Correspondence: Judit VÁRKONYI, 3rd Department of Internal Medicine, Semmelweis University, 12 Eötvös út Budapest H-1121, Hungary; Tel: (361)1754533, Fax: (361)1557183

Click here to get the full-text version in PDF!