PATHOLOGY & ONCOLOGY RESEARCHVol. 3 No. 2, 1997

 Seminar

Molecular Events as Targets of Anticancer Drug Therapy

Adorján ASZALÓS1, Sándor ECKHARDT2

1Food and Drug Administration, Washington DC, USA
2National Institute of Oncology, Budapest, Hungary

 

The aim of this review is to introduce some molecular targets for cancer chemotherapy, with comments on their mode of action, preclinical and clinical results. The representatives of the following groups are covered: phosphorylation inhibitors, protein kinase modulators, receptor antagonists, immunomodulators, differentiating agents, multidrug resistance modulation, telomerase inhibitors, and bioreductive agents. Pathology & Oncology Research, Vol 3, Nr 2, 147-158, 1997

Key words: cancer; molecular targets; chemotherapy


Received: Jan 25, 1997; accepted: May 28, 1997
Correspondence: Adorján ASZALÓS, Food and Drug Administration, , 200 C Street Washington DC 20204, USA; Tel: (202)2054177, Fax: (202)2054758

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