PATHOLOGY & ONCOLOGY RESEARCHVol. 3 No. 3, 1997

 Review

Molecular Cancer Vaccines: Tumor Therapy Using Antigen-Specific Immunizations

Tamás SCHWEIGHOFFER

Department Cell Biology, Boehringer Ingelheim Research and Development, Wien, Austria

 

Vaccination against tumors promises selective destruction of malignant cells by the host's immune system. Molecular cancer vaccines rely on recently identified tumor antigens as immunogens. Tumor antigens can be applied in many forms, as genes in recombinant vectors, as proteins or peptides representing T cell epitopes. Analysis of various aspects indicates some advantage for peptide-based vaccines over the other modalities. Further refinements and extensively monitored clinical trials are necessary to advance molecular cancer vaccines from concepts into powerful therapy. Pathology & Oncology Research, Vol 3, Nr 3, 164-176, 1997

Key words: vaccines; molecular; immunotherapy; tumor


Received: Jun 10, 1997; accepted: Aug 24, 1997
Correspondence: Tamás SCHWEIGHOFFER, Department Cell Biology, Boehringer Ingelheim Research and Development, Dr. Boehringer-Gasse 5 Wien A-1120, Austria; Tel: (43)1-80105258, Fax: (43)1-80105366; E-mail: schweig@bender.co.at

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