Post-transplant Lymphoproliferative Disorders


Department of Pathology, UCLA School of Medicine, Los Angeles, USA


Post-transplant lymphoproliferative disorder (PTLD) is one of the most dreaded complications of orthotopic transplantation. It consists of a heterogeneous group of lymphoproliferative disorders of varying clonal composition, occurring in immunosuppressed organ allograft recipients and is frequently due to EBV infection. It is most common in heart/lung transplants followed by heart, liver, and kidney and rarely in bone marrow transplants. Clinically, PTLD can present in a number of ways ranging from features resembling infectious mononucleosis, lymphoproliferative masses involving both nodal and extranodal locations, to a fulminant form characterized by a combination of peripheral lymphadenopathy, severe metabolic acidosis, organ failure or allograft dysfunction. Pathologically PTLD is characterized by a dense inflammatory infiltrate with a spectrum ranging from that found in infectious mononucleosis to a polymorphous B-cell hyperplasia to that of a monomorphous lymphoma. Analysis of EBV is especially useful for the diagnosis of early cases of PTLD. In addition, immunophenotyping to determine the lymphocyte type (B or T cell type) and monoclonality are most helpful in determining the prognosis. Pathology & Oncology Research, Vol 3, Nr 3, 177-182, 1997

Key words: post-transplant; lymphoproliferation

Received: Sep 1, 1997; accepted: Sep 15, 1997
Correspondence: Klaus J LEWIN, Department of Pathology, UCLA School of Medicine, 10833 Le Conte Ave Los Angeles 90095-1732, USA

Click here to get the full-text version in PDF!