PATHOLOGY & ONCOLOGY RESEARCHVol. 3 No. 3, 1997

 Review

Syndecan-1 - A New Piece in B-cell Puzzle

László KOPPER, Anna SEBESTYÉN, Mónika GALLAI, Ilona KOVALSZKY

1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary

 

Syndecans are transmembrane proteoglycans, with core proteins mainly decorated with heparan sulfate chains. Syndecan-1 is expressed in a tissue-, cell- and differentiation-specific manner. Its extracellular domain can bind via HS chains to matrix elements, to growth factors (especially ''heparin-binding'' proteins) and to certain biological agents. The ectodomain released by proteolysis can also be functionally active. The cytoplasmic domain can take part in signaling processes as well as in modifying cell shape. In hematopoietic cells syndecan-1 is expressed in normal pre-B-cells and plasma cells, as well as in plasmocytoid and lymphoplasmocytoid malignancies. According to our study syndecan-1 is expressed in B-CLL cells both in tissue environment and in circulation. Pathology & Oncology Research, Vol 3, Nr 3, 183-191, 1997

Key words: syndecan-1; heparan sulfate; proteoglycan; hematopoietic cells; B-cells


Received: Aug 2, 1997; accepted: Sep 10, 1997
Correspondence: László KOPPER, 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllõi út 26. Budapest H-1085, Hungary; Tel: (36)(1)1170891, Fax: (36)(1)1170891; E-mail: kopper@korb1.sote.hu

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