PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 3, 1999

 Report

Amphicrine Tumor

László MÁNDOKY

Department of Pathology, Uzsoki Municipal Hospital, Budapest, Hungary

 

The term amphicrine refers to cells, and tumors, which show both exocrine and endocrine features. Author’s aim was to analyse the characteristics of these neoplasms. 40 suspicious cases were reviewed. Mucin-stains (PAS, diastase-PAS, Stains-all, Alcian-blue), immunohistochemistry (antibodies against Neuron-Specific Enolase (NSE), and Chromogranin A (CGA), and electronmicroscopic studies were performed to demonstrate exocrine and/or endocrine features of the tumor cells. By means of these methods, 16 cases turned out to be amphicrine tumors. Among them, there were 4 sinonasal, 1 bronchial, 1 mediastinal, 8 gastrointestinal and 2 suprarenal gland neoplasms. In connection to the subject, a brief review is given of amphicrine tumor, regarding its etiological and pathological aspects. These tumors form a distinct clinicopathological entity and should be separated from both neuroendocrine tumors and adenocarcinomas. Pathology & Oncology Research, Vol 5, Nr 3, 239-244, 1999

Key words: amphicrine; adenocarcinoid; neuroendocrine; mucus granules; dense-core granules


Received: Jun 30, 1999; accepted: Aug 21, 1999
Correspondence: László MÁNDOKY, Department of Pathology, Uzsoki Municipal Hospital, Uzsoki utca 29. Budapest H-1145, Hungary; Tel: +36-12517333 / 1136, Fax: +36-13168022; E-mail: mandlasz@mail.matav.hu

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