PATHOLOGY & ONCOLOGY RESEARCHVol. 3 No. 4, 1997

 Review

Drug-Induced Liver Injury Cholestatic Injury, Acute and Chronic

Claude DEGOTT

Hopital Beajuon, Service D'Anatomie et de Cytologie Pathologique, Clichy, France

 

Cholestasis is the failure of bile to reach duodenum due to three different mechanisms: a. alteration of bile secretion by hepatocytes into the canaliculus with or without liver cell damage; b. obstruction of the intrahepatic bile ducts caused by diseases of ductules or small/medium bile ducts; c. obstruction of extrahepatic bile ducts. This short review focuses on drugs which may induce cholestasis by any of these mechanisms. Pathology & Oncology Research, Vol 3, Nr 4, 260-263, 1997

Key words: cholestasis; drug-induced


Received: Aug 12, 1997; accepted: Sep 2, 1997
Correspondence: Claude DEGOTT, Hopital Beajuon, Service D'Anatomie et de Cytologie Pathologique, 100 bd du Gal-Leclerc Clichy 92118, France; Tel: (33-1)40875464, Fax: (33-1)40870077

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