Role of Complement and Antibodies in the Control and Facilitation of HIV Disease

Zoltán PROHÁSZKA1, Ferenc D TÓTH3, Dénes BÁNHEGYI4, George FÜST2

13rd Department of Medicine, Semmelweis University of Medicine, Budapest, Hungary
2Research Group for Membrane Biology and Immunopathology, National Academy of Sciences, Budapest, Hungary
3Institute of Microbiology, University Medical School, Debrecen, Hungary
4Department of Immunology, St. László Hospital, Budapest, Hungary


In humans the HIV infection results in a chronic disease with a permanent fight between factors controlling HIV and the escape of the virus. Fromthese control mechanisms the present review summarizes the role betwen complement and autoantibodies; the competition of complement and anti-HIV antibodies for binding sites, the role of mannan-binding lectin in the susceptibility to and in the survival after HIV infection, the contribution of complement-dependent enhancing type antibodies to the clinical progression of HIV disease as well as the changing pattern of some autoantibodies (mimicking MHC class II molecules, anti-heat shock protein 60 antibodies and anti-C1q antibodies) which were found to correlate to immunological and clinical parameters. Pathology & Oncology Research, Vol 3, Nr 4, 296-302, 1997

Key words: HIV; complement; gp41; gp120; mannan-binding lectin; enhancing antibodies; autoantibodies; heat-shock protein 60; C1q

Received: Oct 31, 1997; accepted: Nov 26, 1997
Correspondence: Zoltán PROHÁSZKA, 3rd Department of Medicine, Semmelweis University of Medicine, Eötvös út 12. Budapest H-1121, Hungary; Tel: (36-1)3954533/175, Fax: (36-1)1557183; E-mail:

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