PATHOLOGY & ONCOLOGY RESEARCHVol. 5 No. 3, 1999

 Article

Clinical Aspects of Alveolar Rhabdomyosarcoma with Translocation t(1;13)(p36;q14) and Hypotetraploidy

Bastian GUNAWAN1, Bernd GRANZEN2, Uma KELLER2, Gerd STEINAU3, László FÜZESI1, Volker SCHUMPELICK3, Rolf MERTENS2

1Department of Pathology, Georg-August-University, Göttingen, Germany
2Department of Pediatrics, Medical Faculty of the Technical University, Aachen, Germany
3Department of Surgery, Medical Faculty of the Technical University, Aachen, Germany

 

Although most cases of alveolar rhabdomyosarcoma (RMS) are characterized by the chromosomal translocation t(2;13)(q35;q14), several cases have been reported with a variant t(1;13)(p36;q14). We present the clinical, morphological and cytogenetic features of an alveolar RMS in a 4-year-old boy. Chromosomal analysis revealed a hypertriploid to hypotetraploid karyotype with a t(1;13)(p36;q14) in all tumor cells. It appears that alveolar RMS with t(1;13) occurs in younger children and displays a higher incidence to upper and lower extremity than tumors with t(2;13). Pathology & Oncology Research, Vol 5, Nr 3, 211-213, 1999

Key words: alveolar rhabdomyosarcoma; soft tissue; cytogenetics; chromosome


Received: Apr 30, 1999; accepted: Jul 3, 1999
Correspondence: Rolf MERTENS, Department of Pediatrics, Medical Faculty of the Technical University, RWTH, Pauwelsstr. 30 Aachen D-52057, Germany; Tel: 49 2418089941, Fax: 49 2418888492

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