PATHOLOGY & ONCOLOGY RESEARCHVol. 1 No. 1, 1995

 Article

Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen

Béla SZENDE1, Ernő TYIHÁK2, Gyula SZÓKÁN3, György KÁTAY3

11st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Pathology, Budapest, Hungary
2Plant Protection Institute, Hungarian Academy of Sciences, Budapest, Hungary
3Institute of Organic Chemistry, Lóránd Eötvös University, Budapest, Hungary

 

PC-3 human prostate carcinoma cells were treated with 100 mg/ml 1-methyl-ascorbigen (Me-Asc). This treatment resulted in a significant decrease in tumor cell number in parallel with an increase in apoptotic cells. The formaldehyde (HCHO) level in the culture medium was also increased. Dimedone (Di), a known capture molecule forming formal-demethone with HCHO, applied simultaneously with Me-Asc in 10 mg/ml doses diminished the apoptosis-inducing effect of Me-Asc. The possible role of in situ generated HCHO in the induction of apoptosis is discussed. Pathology & Oncology Research, Vol 1, Nr 1, 38-42, 1995

Key words: formaldehyde; apoptosis; methylascorbigen


Received: Dec 3, 1994; accepted: Feb 20, 1995
Correspondence: Béla SZENDE, 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Pathology, Üllõi út 26. Budapest 1085, Hungary; Tel: 36-1-2100270, Fax: 36-1-1335784

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