PATHOLOGY & ONCOLOGY RESEARCHVol. 1 No. 1, 1995

 Article

Complement Synthesis Influencing Factors Produced by Acute Myeloid Leukemia Blast Cells

Béla SCHMIDT, Márta VÁLAY, Sarolta NAHAJEVSZKY, Ervin PITLIK, György FÜST

Department of Immunopathology, National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

 

In a previous study, we found hypercomplementaemia in the sera of acute myeloid leukemia patients. In this study we show that the supernatants of mononuclear cells, derived from peripheral blood taken in the blastic phase, from patients with acute myeloid leukemia (CM-AML) increased the in vitro complement protein synthesis of HepG2 hepatocellular carcinoma cells. This effect of CM-AML was mediated by heat labile soluble factors and involved the synthesis of mRNA and protein. Inhibition experiments with anti-cytokine antibodies and immunoaffinity chromatography revealed that this effect of CM-AML is mostly mediated by IL-1 and IL-6. Pathology & Oncology Research, Vol 1, Nr 1, 54-59, 1995

Key words: AML; complement factor B; C1-INH; C3; C4; IL-1b; IL-2; IL-6; TNF


Received: Mar 25, 1995; accepted: Jun 6, 1995
Correspondence: György FÜST, Department of Immunopathology, National Institute of Haematology, Blood Transfusion and Immunology, Daróczi út 24. Budapest H-1502, Hungary

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