PATHOLOGY & ONCOLOGY RESEARCHVol. 1 No. 1, 1995

 Article

Modification of Acute and Chronic Liver Damage by Thiazolidine Compounds

András DIVALD1, Zoltán GYÖRGYDEÁK2, Ferenc TÍMÁR1, Attila ZALATNAI1, Rezsõ BOGNÁR2, Gábor HORVÁTH2, Károly LAPIS1, András JENEY1

1Ist Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary
2Institute of Organic Chemistry, Kossuth Lajos University, Debrecen, Hungary

 

As high sulfhydril levels were shown to reduce the action of agents causing tissueinjury, increasing glutathion concentrations may have cytoprotective potential. In this study the hepatoprotective effects of several derivatives of 4carboxy5,5dimethyl thiazolidine, a modulator of glutathion metabolism were studied in rat liver damaged with CCl4. It was found that 4(S) carboxy 5,5dimethyl2 (5'nitro2furyl) thiazolidine (dimethylthiazolidinenitrofuran: DTNF) had the most significant hepatoprotective action; therefore it was subjected to detailed investigation in various models for acute and chronic liver injury. This compound was shown to ameliorate allylalcohol induced liver injury in rats, galactosamine induced hepatitis of mice and CCl4 induced chronic liver damage in rats. Our study on protein synthesis in primary hepatocyte suspension culture showed that cell injury induced by CCl4 could be reduced in the presence of this thiazolidine compound. Pathology & Oncology Research, Vol 1, Nr 1, 60-63, 1995

Key words: thiazolidine; liver damage; cirrhosis; hepatoprotection


Received: Dec 15, 1994; accepted: Mar 30, 1995
Correspondence: András JENEY, Ist Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllõi út 26. Budapest H-1085, Hungary; Tel: 36-1-210-2686

Click here to get the full-text version in PDF!
ad