PATHOLOGY & ONCOLOGY RESEARCHVol. 1 No. 1, 1995

 Review

Role of Proteoglycans in Tumor Progression

József TÍMÁR, András JENEY, Ilona KOVALSZKY, László KOPPER

1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary

 

Data is now starting to accumulate on the differential expression of PGs in tumor cells of various invasive/metastatic potential. This is not so surprising if one considers the key functions that PGs play in the regulation of cell proliferation, adhesion and motility. However, characterization of PG expression in individual tumor types still awaits further detailed studies. Data on melanomas clearly indicate that PG phenotype is both specific and also promiscuous in a sense that ectopic expression of certain tissue specific PGs can occur in various tumors. Expression of a metastatic phenotype-specific splice variants of CD44 provides an example for the possible marker-function of PG. This also raises the hope that some PGs could be used as diagnostic/prognostic tools in pathology or even as a therapeutic targets against tumor dissemination. On the other hand, specific glycanation inhibitors may also be used for the modulation of tumor PG exist and the invasive phenotype. Pathology & Oncology Research, Vol 1, Nr 1, 85-93, 1995

Key words: proteoglycan; metastasis; glycosaminoglycan; invasion


Received: May 12, 1995; accepted: Jun 22, 1995
Correspondence: József TÍMÁR, 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllõi út 26. Budapest H-1085, Hungary; Tel: 36-1-1335740, Fax: 36-1-1335784

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